Matthew Holm was born and raised in the suburbs of Philadelphia. He grew up reading his four older siblings' comic books and comic strip collections, and hoped he might one day grow up to draw a daily newspaper comic strip. While studying English and Art at Pennsylvania State University, he drew weekly editorial cartoons for the school newspaper. After college, he worked in New York City as a writer and editor for Hearst's Country Living Magazine, and drew a daily web comic in his spare time (before the term "web comic" really existed). He first began working with his sister, Jennifer, as a copy editor and fact-checker for her Boston Jane novels. Later, he illustrated several pages of comics for her book Middle School Is Worse than Meatloaf. When Jennifer came to him in 2001 with the idea of making a comic book with a female heroine named Babymouse, he again picked up his pen and the two worked out the ideas for what became one of the first graphic novel series written specifically for children. Today, he continues to collaborate with his sister on several graphic novels each year, both for the Babymouse and the Squish series. He currently lives in Portland, Oregon, with his wife and dog.